Evidence-Based Notes on Lipids, Insulin, VO2 Max & Preventive MRI.

Atherosclerotic plaque initiation scales directly with the molar concentration of apolipoprotein B-100 particles crossing the arterial endothelium—not cholesterol mass inside LDL.

Pancreatic beta-cell hypersecretion masks rising peripheral insulin resistance for a decade while fasting glucose and HbA1c still print 'within normal reference range.'

No pharmacologic intervention matches the hazard-ratio reduction observed when moving from low cardiorespiratory fitness into the upper quartile for age and sex.

Whole-body MRI only improves net healthspan when paired with subspecialty dual-reading, prior-scan volumetric comparison, and pre-test probability thresholds.